Wiki's allow collaborative editing of web-sites.

Most wikis like the original c2 wiki allow anonymous users to modify the web pages, including complete deletion of contents or insertion of external links. Most of them do maintain backups, few don't.

A targeted script based attack can very easily modify/delete a large number of these pages by crawling through the wiki web. I am sure the admin's will try to recover, however they are pretty much helpless against a dedicated hacker, who can not only use the anonymizer services to post from different IP's, but may also use the drones normally used for DDOS attacks.

This is at least equivalent to denial of service attack in that it prevents people from viewing these web sites contents, which often host useful product & services related information. It is actually worse as it can replace the content with objectionable/inappropriate contents. It also obviously has the capability to surreptiously post links to adult/casino/mortgage sites. Link spamming can take on a whole new dimension - wiki spamming.

One solution is to allow modification to members who go through a registration process.
The process must employ some way to prevent automatic registration like letter recognition from an image etc. (like Hotmail email registration)
That way the problem can be contained and manageable as scripts cannot be used to affect the sites. Also protective actions can be taken like removing errant members, email verification etc.
Once the scripts are removed from the equation, the rest is easy.

A simpler solution which doesn't require registration is to ask the modifier to do letter recognition from an image. This simple measure retains the anonymous modifibility of wiki, yet locks out automatic scripts. It is still possible for humans to spread spamlove through wiki, however the effect will be manageable. And there is always option 1 which requires modifiers to register.