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One of the world's most powerful supercomputers has simulated a moment in the life of a real virus.����һ����������ǿ��ij��������ģ��ʱ�̣���ѧУ�����һ������IJ����� The simulation is the first to capture a whole biological organism in such intricate molecular detail.�������״β�׽��������л��壬�����ִ��۸��ӵķ���ϸ�ڡ�

"Computational Biology has finally reached the level of sophistication and utility of the 1970��s video game Pong. ����������ѧ�����ڴﵽ���Ƚ�ˮƽ��ʵ����1970�����Ƶ��Ϸƹ�ҡ�

But it sounds like we should reach beyond Space Invaders and Pac Man levels in 5 years��.������������������Ӧ�ôﵽ��Խ�ռ������ߺ͸���������ĿίԱ������������ꡭ �� �� Maybe we��ll actually have the bioinfo equivalent of Excel by then."Ҳ�����ǻ���ʵ��bioinfo�൱��Excel�У�Ȼ�� ��

Running on a machine at the National Center for Supercomputing Applications, Urbana, the program calculated how each of the million or so atoms in the virus and a surrounding drop of salt water was interacting with almost every other atom every femtosecond, or millionth of a billionth of a second.������һ̨�����ڹ�ҳ�������Ӧ�����ģ�����ɣ��üƻ�����μ����ÿ�����ʹԭ���еIJ�������Χ��һ����ˮ�ǻ����ļ���ÿһ������ԭ��ÿ���룬������֮һһ��1000000000��֮1һ���ӡ�

The team managed to model the entire virus in action for 50 billionths of a second.�Ŷӹ���ģ�ͣ�����������ж�1000000000��֮50һ���ӡ� Such a task would take a desktop computer around 35 years, says Schulten.����һ�����񽫲�ȡ�������͵���Լ35������˵schulten �� "This is just a first glimpse," he says. ����ֻ�ǵ�һ�ο����� ����˵�� "But it looks gorgeous." ���������������� ��

The model shows that the virus coat collapses without its genetic material.��ģ�ͱ������ò�����DZ�����δ�����Ŵ����ʡ� This suggests that, when reproducing, the virus builds its coat around the genetic material rather than inserting the genetic material into a complete coat.������������ƣ����������Լ������£���Χ���Ŵ����ʣ����Dz�����Ŵ����ʣ�һ������Ĵ��¡� "We saw something that is truly revolutionary," Schulten says. �����ǿ����Ķ���������ĸ��� �� schulten˵��

Ultimately, computational biologists would like to simulate larger viruses such as influenza or the complex biological systems in a cell - and for longer periods, such as the thousandths of a second that it might take to observe proteins in a cell switch a gene off.���գ���������ѧ����ģ��ϴ�IJ����������У����ӵ�����ϵͳ��һ���η�-�͸��ʱ�䣬����ǧ��֮һ�ڶ�������ܲ�ȡ�Ĺ۲쵰������ϸ��ת����С���� These computer models should allow researchers to discover details about such processes that they may miss by observing a real virus.��Щ�����ģ��Ӧ�������о���Ա���֣���ϸ�˽����ֹ�̣����ǿ��ܻ��ʧͨ��۲�һ������IJ�����

But such simulations will not become possible until the next generation of supercomputers are built in the next five years, Schulten says.������ģ�⽫�����Ϊ���ܣ�ֱ����һ��ij���������ǽ�����δ�������ڣ� schulten˵��

Source:������Դ�� Nature����