Researchers at St. Paul��s Hospital and Vancouver General Hospital are developing a revolutionary new test to diagnose and facilitate treatment of organ rejection in transplant patients.�о���Ա��ʥ��»ҽԺ���¸绪��ҽԺ�����ƶ�һ������Ե��µĿ��飬����Ϻ������ṩ����������ųⷴӦ����ֲ���ߡ�

Patients with end-stage vital organ failure depend on transplantation, but the process has its remaining challenges.������ĩ�����ٹ���˥�ߵ���Ҫ��������ֲ������һ�������ʣ�����ս�� Immune cells that normally protect patients can cause rejection and destruction of the very organ intended to save their life.����ϸ��ͨ���������˿ɵ����ųⷴӦ����ٷdz����ٴ���������ǵ����� To test for rejection, patients must undergo uncomfortable and invasive biopsies.�����ųⷴӦ�����߱�����ܲ�����������Ի�졣 Patients must also take drugs that inhibit rejection by suppressing the immune response, and which can have serious side effects.���˻������ȡҩ�������ųⷴӦ���������߷�Ӧ�������������صĸ����á�

Project researchers seek to define which biomarkers��for example, substances found in the blood or other body fluids¾can be used as a diagnostic and prognostic test for organ rejection and immunosuppressive therapy response.��Ŀ�о���ԱѰ��綨��Щ�����־��-������˵�����ʵķ��֣���ѪҺ��������Һ¾�ɱ�������Ϊ��ϼ�Ԥ���жϲ��������ųⷴӦ�������������Ƶķ�Ӧ�� Being able to monitor and predict rejection using a simple blood test will significantly reduce intrusive and expensive diagnostic procedures.�ܹ���غ�Ԥ���ų�ʹ��һ���򵥵�ѪҺ���Խ������������ԺͰ������ϳ���

��These new tools are critical in order to produce an affordable, accurate, and widely useful test to determine whether rejection is occurring and how a patient��s transplanted organ is faring,�� says Dr. Rob McMaster, project co-lead, Director of the Immunity and Infection Research Centre at the Vancouver Coastal Health Research Institute, and Director of Transplant Immunology Research for the BC Transplant Society. ����Щ�¹�����������Ҫ�ģ��Ա����һ����������ģ�׼ȷ���㷺���õIJ��ԣ���ȷ���Ƿ��ųⷴӦ�ķ����Լ���β��˵���ֲ�����DZ��֣���ʿ˵�� ���׶���˹���͹������˹�أ���Ŀ������Ǧ���������߹��ܺ͸�Ⱦ�о��������¸绪�ذ������о�Ժ��������ֲ����ѧ�о�Ϊ��Ԫǰ��ֲ����ᡣ

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